Drug interactions
Octreotide + Promazine
Severity: Moderate
Octreotide and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine that can prolong the QT interval. Octreotide may add to this through bradycardia and conduction changes, raising the risk of torsades de pointes.
What this interaction means in plain words
Octreotide and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation; promazine blocks cardiac potassium channels and octreotide causes bradycardia.
What to do
Check baseline ECG and electrolytes and monitor QTc during co-treatment. Prefer an antipsychotic with less QT effect in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Promazine?
MediHelp rates the interaction as moderate. Octreotide and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine is a phenothiazine that can prolong the QT interval. Octreotide may add to this through bradycardia and conduction changes, raising the risk of torsades de pointes.
How serious is the interaction between Octreotide and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor QTc during co-treatment. Prefer an antipsychotic with less QT effect in patients with other risk factors.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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