Drug interactions
Octreotide + Romidepsin
Severity: Moderate
Octreotide and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QTc prolongation, and octreotide may also cause bradycardia. Together they may increase the risk of ventricular arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Octreotide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check baseline ECG, potassium and magnesium, and repeat during treatment. Replace deficient electrolytes before each romidepsin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Romidepsin?
MediHelp rates the interaction as moderate. Octreotide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QTc prolongation, and octreotide may also cause bradycardia. Together they may increase the risk of ventricular arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Octreotide and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, potassium and magnesium, and repeat during treatment. Replace deficient electrolytes before each romidepsin dose.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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