Drug interactions
Octreotide + Telotristat ethyl
Severity: Moderate
Octreotide and Telotristat ethyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide may reduce systemic exposure to telotristat ethyl, potentially weakening its control of carcinoid syndrome diarrhea. The effect is most relevant with short-acting octreotide given close to telotristat.
What this interaction means in plain words
Octreotide and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not established; it may involve reduced absorption of telotristat.
What to do
Give short-acting octreotide at least 30 minutes after telotristat ethyl. Monitor bowel movement frequency and consider dose adjustment if symptom control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Octreotide and Telotristat ethyl, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Telotristat ethyl?
MediHelp rates the interaction as moderate. Octreotide and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide may reduce systemic exposure to telotristat ethyl, potentially weakening its control of carcinoid syndrome diarrhea. The effect is most relevant with short-acting octreotide given close to telotristat.
How serious is the interaction between Octreotide and Telotristat ethyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give short-acting octreotide at least 30 minutes after telotristat ethyl. Monitor bowel movement frequency and consider dose adjustment if symptom control worsens.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
