Drug interactions
Olanzapine + Papaveretum
Severity: Major
Olanzapine and Papaveretum: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, so with olanzapine it can cause profound sedation, hypotension and respiratory depression.
What this interaction means in plain words
Olanzapine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism and olanzapine's sedative effects.
What to do
Reduce the opioid dose where possible and monitor sedation, respiratory rate and blood pressure. Avoid other CNS depressants.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Papaveretum?
MediHelp rates the interaction as major. Olanzapine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids including morphine, so with olanzapine it can cause profound sedation, hypotension and respiratory depression.
How serious is the interaction between Olanzapine and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the opioid dose where possible and monitor sedation, respiratory rate and blood pressure. Avoid other CNS depressants.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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