Drug interactions
Olanzapine + Phendimetrazine
Severity: Moderate
Olanzapine and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic with stimulant effects, and antipsychotics may oppose its actions. Stimulants can also aggravate psychosis, so the combination may reduce psychiatric stability. Clinically significant sedation interaction is uncertain.
What this interaction means in plain words
Olanzapine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects of dopaminergic and noradrenergic stimulation versus dopamine antagonism.
What to do
Monitor mental state, heart rate and blood pressure. Consider a non-stimulant approach to weight management in patients with psychotic illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Phendimetrazine?
MediHelp rates the interaction as moderate. Olanzapine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic with stimulant effects, and antipsychotics may oppose its actions. Stimulants can also aggravate psychosis, so the combination may reduce psychiatric stability. Clinically significant sedation interaction is uncertain.
How serious is the interaction between Olanzapine and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental state, heart rate and blood pressure. Consider a non-stimulant approach to weight management in patients with psychotic illness.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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