Drug interactions
Olanzapine + Protriptyline
Severity: Moderate
Olanzapine and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, anticholinergic effects and QT prolongation, so the combination raises the risk of arrhythmia, drowsiness and orthostatic hypotension. Olanzapine may also lower the seizure threshold along with tricyclics.
What this interaction means in plain words
Olanzapine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedative, anticholinergic and QT-prolonging pharmacodynamic effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium; monitor QTc and for sedation or anticholinergic toxicity. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Protriptyline?
MediHelp rates the interaction as moderate. Olanzapine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, anticholinergic effects and QT prolongation, so the combination raises the risk of arrhythmia, drowsiness and orthostatic hypotension. Olanzapine may also lower the seizure threshold along with tricyclics.
How serious is the interaction between Olanzapine and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium; monitor QTc and for sedation or anticholinergic toxicity. Avoid adding other QT-prolonging drugs.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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