Drug interactions
Olanzapine + Quazepam
Severity: Moderate
Olanzapine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic and, with olanzapine, can cause additive sedation, dizziness and psychomotor impairment. Respiratory depression and hypotension are additional concerns, especially with parenteral olanzapine and in elderly patients.
What this interaction means in plain words
Olanzapine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and olanzapine's antihistaminic and antidopaminergic effects.
What to do
Use the lowest effective doses and counsel patients on driving and alcohol avoidance. Monitor sedation, blood pressure and respiration, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Quazepam?
MediHelp rates the interaction as moderate. Olanzapine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine hypnotic and, with olanzapine, can cause additive sedation, dizziness and psychomotor impairment. Respiratory depression and hypotension are additional concerns, especially with parenteral olanzapine and in elderly patients.
How serious is the interaction between Olanzapine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients on driving and alcohol avoidance. Monitor sedation, blood pressure and respiration, particularly in older patients.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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