Drug interactions
Olanzapine + Romidepsin
Severity: Moderate
Olanzapine and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with ECG changes including QT prolongation, and olanzapine has modest QT effects. Together they may increase the risk of ventricular arrhythmia, especially with electrolyte disturbance.
What this interaction means in plain words
Olanzapine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Check baseline ECG and keep potassium and magnesium within normal range. Monitor ECG during treatment and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Romidepsin?
MediHelp rates the interaction as moderate. Olanzapine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin has been associated with ECG changes including QT prolongation, and olanzapine has modest QT effects. Together they may increase the risk of ventricular arrhythmia, especially with electrolyte disturbance.
How serious is the interaction between Olanzapine and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and keep potassium and magnesium within normal range. Monitor ECG during treatment and avoid other QT-prolonging drugs.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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