Drug interactions
Olanzapine + Scullcap
Severity: Minor
Olanzapine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap herbal products are traditionally used for calming effects and may add to olanzapine's sedation. Evidence is limited and product content varies.
What this interaction means in plain words
Olanzapine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive CNS depression, possibly via GABAergic activity of skullcap constituents.
What to do
Advise patients to avoid skullcap or monitor for excess drowsiness, and counsel against driving if sedated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Scullcap?
MediHelp rates the interaction as minor. Olanzapine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap herbal products are traditionally used for calming effects and may add to olanzapine's sedation. Evidence is limited and product content varies.
How serious is the interaction between Olanzapine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid skullcap or monitor for excess drowsiness, and counsel against driving if sedated.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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