Drug interactions
Olanzapine + Somatropin
Severity: Minor
Olanzapine and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase the activity of some cytochrome P450 enzymes, which could lower olanzapine exposure. The effect is predicted from limited data on other substrates and is probably small.
What this interaction means in plain words
Olanzapine and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olanzapine belongs to Central Nervous System; Somatropin belongs to Endocrine.
Why it happens
Possible induction of CYP-mediated metabolism, including CYP1A2, by somatropin.
What to do
No routine dose change is needed. Watch for reduced antipsychotic response when somatropin is started and adjust olanzapine if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Olanzapine with Somatropin?
MediHelp rates the interaction as minor. Olanzapine and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase the activity of some cytochrome P450 enzymes, which could lower olanzapine exposure. The effect is predicted from limited data on other substrates and is probably small.
How serious is the interaction between Olanzapine and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for reduced antipsychotic response when somatropin is started and adjust olanzapine if symptoms worsen.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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