Drug interactions
Olanzapine + Sufentanil sl
Severity: Major
Olanzapine and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with other CNS depressants such as olanzapine can cause profound sedation, hypotension, respiratory depression and death. Sublingual sufentanil is potent, so this risk is clinically important.
What this interaction means in plain words
Olanzapine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with additive hypotension.
What to do
Reserve the combination for patients with no alternatives, using the lowest doses and shortest duration. Monitor closely for sedation, respiratory depression and hypotension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Sufentanil sl?
MediHelp rates the interaction as major. Olanzapine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with other CNS depressants such as olanzapine can cause profound sedation, hypotension, respiratory depression and death. Sublingual sufentanil is potent, so this risk is clinically important.
How serious is the interaction between Olanzapine and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no alternatives, using the lowest doses and shortest duration. Monitor closely for sedation, respiratory depression and hypotension.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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