Drug interactions
Olanzapine + Thiothixene
Severity: Moderate
Olanzapine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics increases the risk of QT prolongation, sedation, anticholinergic effects and extrapyramidal symptoms. Therapeutic benefit of the combination is poorly established.
What this interaction means in plain words
Olanzapine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and dopamine D2 blockade with overlapping adverse effects.
What to do
Avoid antipsychotic polypharmacy where possible. If both are used, monitor the ECG and for extrapyramidal and sedative effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine and Thiothixene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Thiothixene?
MediHelp rates the interaction as moderate. Olanzapine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics increases the risk of QT prolongation, sedation, anticholinergic effects and extrapyramidal symptoms. Therapeutic benefit of the combination is poorly established.
How serious is the interaction between Olanzapine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible. If both are used, monitor the ECG and for extrapyramidal and sedative effects.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
