Drug interactions
Olanzapine + Triazolam
Severity: Moderate
Olanzapine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine and triazolam both cause sedation, so combined use increases drowsiness, impaired coordination and the risk of falls. Hypotension and respiratory depression may occur, especially in older or debilitated patients.
What this interaction means in plain words
Olanzapine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through different receptor mechanisms.
What to do
Use the lowest effective doses and monitor sedation and blood pressure; counsel patients about driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Triazolam?
MediHelp rates the interaction as moderate. Olanzapine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine and triazolam both cause sedation, so combined use increases drowsiness, impaired coordination and the risk of falls. Hypotension and respiratory depression may occur, especially in older or debilitated patients.
How serious is the interaction between Olanzapine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure; counsel patients about driving and fall risk.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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