Drug interactions
Olanzapine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Olanzapine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can prolong the QT interval, and vilanterol, a long-acting beta-2 agonist, can cause tachycardia, hypokalemia and QT effects. Together they may add to the risk of arrhythmia, although inhaled systemic exposure is low and olanzapine's QT effect is modest.
What this interaction means in plain words
Olanzapine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic cardiac effects: olanzapine's modest QT prolongation plus beta-2 agonist-mediated tachycardia and hypokalemia.
What to do
Use the combination at standard inhaled doses and monitor heart rate and palpitations. Check ECG and potassium in patients with other QT risk factors or existing cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Olanzapine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can prolong the QT interval, and vilanterol, a long-acting beta-2 agonist, can cause tachycardia, hypokalemia and QT effects. Together they may add to the risk of arrhythmia, although inhaled systemic exposure is low and olanzapine's QT effect is modest.
How serious is the interaction between Olanzapine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the combination at standard inhaled doses and monitor heart rate and palpitations. Check ECG and potassium in patients with other QT risk factors or existing cardiac disease.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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