Drug interactions
Olanzapine + Yohimbine
Severity: Minor
Olanzapine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that stimulates the sympathetic system and may cause anxiety, agitation and blood pressure changes, which could oppose antipsychotic effects. The net clinical effect with olanzapine is unclear.
What this interaction means in plain words
Olanzapine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects; the mechanism is not well established.
What to do
Monitor for agitation, anxiety and blood pressure changes, and avoid yohimbine in patients with psychotic or anxiety disorders if possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine and Yohimbine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Yohimbine?
MediHelp rates the interaction as minor. Olanzapine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is an alpha-2 antagonist that stimulates the sympathetic system and may cause anxiety, agitation and blood pressure changes, which could oppose antipsychotic effects. The net clinical effect with olanzapine is unclear.
How serious is the interaction between Olanzapine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, anxiety and blood pressure changes, and avoid yohimbine in patients with psychotic or anxiety disorders if possible.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
