Drug interactions
Olanzapine / samidorphan + Olmesartan
Severity: Moderate
Olanzapine / samidorphan and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension, which may add to the blood pressure lowering of olmesartan. Patients may experience dizziness, falls or syncope, particularly at initiation or after dose increases.
What this interaction means in plain words
Olanzapine / samidorphan and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect from olanzapine alpha-1 adrenergic blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure and orthostatic symptoms, particularly when starting or titrating. Reduce the olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Olmesartan?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension, which may add to the blood pressure lowering of olmesartan. Patients may experience dizziness, falls or syncope, particularly at initiation or after dose increases.
How serious is the interaction between Olanzapine / samidorphan and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly when starting or titrating. Reduce the olmesartan dose if hypotension occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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