Drug interactions
Olanzapine / samidorphan + Perindopril
Severity: Moderate
Olanzapine / samidorphan and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may enhance the effect of antihypertensives. Combination with perindopril may increase the risk of dizziness, hypotension and falls.
What this interaction means in plain words
Olanzapine / samidorphan and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotension from olanzapine alpha-adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure, especially during initiation and dose increases, and counsel patients about orthostatic symptoms. Lower the perindopril dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine / samidorphan and Perindopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Perindopril?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension and may enhance the effect of antihypertensives. Combination with perindopril may increase the risk of dizziness, hypotension and falls.
How serious is the interaction between Olanzapine / samidorphan and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially during initiation and dose increases, and counsel patients about orthostatic symptoms. Lower the perindopril dose if hypotension develops.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
