Drug interactions
Olanzapine / samidorphan + Propranolol
Severity: Moderate
Olanzapine / samidorphan and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may enhance the effect of antihypertensives such as propranolol. The combination can produce dizziness, syncope or falls.
What this interaction means in plain words
Olanzapine / samidorphan and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from olanzapine alpha-1 adrenergic antagonism and beta-blockade.
What to do
Monitor blood pressure and orthostatic symptoms, especially at initiation and dose changes. Reduce the propranolol dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Propranolol?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension and may enhance the effect of antihypertensives such as propranolol. The combination can produce dizziness, syncope or falls.
How serious is the interaction between Olanzapine / samidorphan and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially at initiation and dose changes. Reduce the propranolol dose if hypotension develops.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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