Drug interactions
Olanzapine / samidorphan + Telmisartan-amlodipine
Severity: Moderate
Olanzapine / samidorphan and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension, and this may add to the blood pressure lowering of telmisartan and amlodipine. Patients may experience dizziness, syncope or falls, particularly when starting therapy or increasing doses.
What this interaction means in plain words
Olanzapine / samidorphan and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects from olanzapine alpha-adrenergic blockade and the antihypertensive agents.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either therapy. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension, and this may add to the blood pressure lowering of telmisartan and amlodipine. Patients may experience dizziness, syncope or falls, particularly when starting therapy or increasing doses.
How serious is the interaction between Olanzapine / samidorphan and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either therapy. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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