Drug interactions
Olanzapine / samidorphan + Triprolidine
Severity: Moderate
Olanzapine / samidorphan and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has antimuscarinic activity and triprolidine is an anticholinergic antihistamine. Together they may increase constipation, urinary retention and sedation, with a risk of severe gastrointestinal hypomotility.
What this interaction means in plain words
Olanzapine / samidorphan and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic and sedative effects.
What to do
Monitor bowel function and sedation, and counsel the patient to report constipation or abdominal distension. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Frequently asked questions
Can I take Olanzapine / samidorphan with Triprolidine?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has antimuscarinic activity and triprolidine is an anticholinergic antihistamine. Together they may increase constipation, urinary retention and sedation, with a risk of severe gastrointestinal hypomotility.
How serious is the interaction between Olanzapine / samidorphan and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and sedation, and counsel the patient to report constipation or abdominal distension. Consider a non-sedating antihistamine.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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