Drug interactions
Olanzapine / samidorphan + Venlafaxine
Severity: Moderate
Olanzapine / samidorphan and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause sedation and orthostatic hypotension, and venlafaxine may add to CNS effects and affect blood pressure. Serotonergic and dopamine-blocking effects may also rarely contribute to serotonin syndrome or neuroleptic malignant syndrome.
What this interaction means in plain words
Olanzapine / samidorphan and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and hemodynamic effects plus overlapping serotonergic and dopaminergic pharmacology.
What to do
Monitor for sedation, orthostatic hypotension and signs of serotonin toxicity, especially when starting or increasing doses. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Venlafaxine?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause sedation and orthostatic hypotension, and venlafaxine may add to CNS effects and affect blood pressure. Serotonergic and dopamine-blocking effects may also rarely contribute to serotonin syndrome or neuroleptic malignant syndrome.
How serious is the interaction between Olanzapine / samidorphan and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and signs of serotonin toxicity, especially when starting or increasing doses. Counsel patients to rise slowly.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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