Drug interactions
Olaparib + Thioguanine
Severity: Moderate
Olaparib and Thioguanine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, and olaparib frequently causes anemia, neutropenia and thrombocytopenia. Combined use may produce more severe or prolonged cytopenias.
What this interaction means in plain words
Olaparib and Thioguanine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olaparib belongs to Oncology; Thioguanine belongs to Oncology.
Why it happens
Additive myelosuppression through DNA-damaging and PARP-inhibitory effects.
What to do
Monitor complete blood counts regularly and reduce or interrupt either drug for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioguanine
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Thioguanine?
MediHelp rates the interaction as moderate. Olaparib and Thioguanine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, and olaparib frequently causes anemia, neutropenia and thrombocytopenia. Combined use may produce more severe or prolonged cytopenias.
How serious is the interaction between Olaparib and Thioguanine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce or interrupt either drug for significant cytopenias.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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