Drug interactions
Olmesartan + Parecoxib
Severity: Moderate
Olmesartan and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, converted to valdecoxib, may reduce the antihypertensive effect of olmesartan and raise the risk of acute kidney injury, particularly in elderly or volume-depleted patients. Hyperkalemia can also occur.
What this interaction means in plain words
Olmesartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandin synthesis, lowering renal perfusion and opposing ARB effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Keep parecoxib use brief and avoid it in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olmesartan and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Parecoxib?
MediHelp rates the interaction as moderate. Olmesartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, converted to valdecoxib, may reduce the antihypertensive effect of olmesartan and raise the risk of acute kidney injury, particularly in elderly or volume-depleted patients. Hyperkalemia can also occur.
How serious is the interaction between Olmesartan and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Keep parecoxib use brief and avoid it in patients with renal impairment.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
