Drug interactions
Olmesartan + Penbutolol
Severity: Minor
Olmesartan and Penbutolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan and the beta-blocker penbutolol are both antihypertensives, and combining them gives additive blood pressure lowering that is often intended. Both may cause hypotension, and olmesartan is contraindicated in pregnancy. Beta-blockers can modestly affect potassium handling, but a clinically important rise is uncommon.
What this interaction means in plain words
Olmesartan and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering from angiotensin II receptor blockade and beta-adrenergic blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Confirm that women of childbearing potential are not pregnant and use effective contraception.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olmesartan and Penbutolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Penbutolol?
MediHelp rates the interaction as minor. Olmesartan and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olmesartan and the beta-blocker penbutolol are both antihypertensives, and combining them gives additive blood pressure lowering that is often intended. Both may cause hypotension, and olmesartan is contraindicated in pregnancy. Beta-blockers can modestly affect potassium handling, but a clinically important rise is uncommon.
How serious is the interaction between Olmesartan and Penbutolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Confirm that women of childbearing potential are not pregnant and use effective contraception.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
