Drug interactions
Olmesartan + Propranolol
Severity: Moderate
Olmesartan and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combined use gives additive effects that are usually therapeutic but may cause hypotension or dizziness. Both can also modestly raise serum potassium, and olmesartan is harmful in pregnancy independent of propranolol.
What this interaction means in plain words
Olmesartan and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olmesartan belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with angiotensin receptor blockade reducing aldosterone-mediated potassium excretion and beta-blockade impairing cellular potassium uptake.
What to do
Monitor blood pressure and serum potassium, especially in renal impairment or diabetes. Avoid in pregnancy because of olmesartan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Propranolol?
MediHelp rates the interaction as moderate. Olmesartan and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combined use gives additive effects that are usually therapeutic but may cause hypotension or dizziness. Both can also modestly raise serum potassium, and olmesartan is harmful in pregnancy independent of propranolol.
How serious is the interaction between Olmesartan and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium, especially in renal impairment or diabetes. Avoid in pregnancy because of olmesartan.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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