Drug interactions
Olmesartan + Sacubitril / valsartan
Severity: Major
Olmesartan and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two angiotensin receptor blockers gives dual blockade without added benefit and increases the risk of hypotension, hyperkalemia and renal dysfunction. Valsartan within the combination already provides full ARB effect.
What this interaction means in plain words
Olmesartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate angiotensin II type 1 receptor blockade producing additive hemodynamic, aldosterone-suppressing and renal effects.
What to do
Avoid using olmesartan with sacubitril/valsartan and stop olmesartan when the combination is started. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Sacubitril / valsartan?
MediHelp rates the interaction as major. Olmesartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two angiotensin receptor blockers gives dual blockade without added benefit and increases the risk of hypotension, hyperkalemia and renal dysfunction. Valsartan within the combination already provides full ARB effect.
How serious is the interaction between Olmesartan and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using olmesartan with sacubitril/valsartan and stop olmesartan when the combination is started. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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