Drug interactions
Olmesartan + Salicylates
Severity: Minor
Olmesartan and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, but at higher doses they may blunt the antihypertensive effect of olmesartan and impair renal function in volume-depleted or older patients.
What this interaction means in plain words
Olmesartan and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of vasodilatory renal prostaglandins can reduce renal perfusion and antagonize ARB effect.
What to do
Monitor blood pressure and renal function if high-dose salicylates are used regularly, and ensure adequate hydration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Salicylates?
MediHelp rates the interaction as minor. Olmesartan and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, but at higher doses they may blunt the antihypertensive effect of olmesartan and impair renal function in volume-depleted or older patients.
How serious is the interaction between Olmesartan and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if high-dose salicylates are used regularly, and ensure adequate hydration.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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