Drug interactions
Olmesartan + Salsalate
Severity: Moderate
Olmesartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID that can reduce the blood pressure lowering effect of olmesartan. In older or volume-depleted patients the combination may also worsen renal function and raise potassium.
What this interaction means in plain words
Olmesartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ARB effect, adding risk of acute kidney injury and hyperkalemia.
What to do
Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated. Use the lowest effective salsalate dose or choose an alternative analgesic like paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Salsalate?
MediHelp rates the interaction as moderate. Olmesartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID that can reduce the blood pressure lowering effect of olmesartan. In older or volume-depleted patients the combination may also worsen renal function and raise potassium.
How serious is the interaction between Olmesartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated. Use the lowest effective salsalate dose or choose an alternative analgesic like paracetamol.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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