Drug interactions
Olmesartan + Sofosbuvir / velpatasvir
Severity: Minor
Olmesartan and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits intestinal and hepatic OATP transporters and may raise olmesartan concentrations. The result is possible enhanced blood pressure lowering or dose-related adverse effects.
What this interaction means in plain words
Olmesartan and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Velpatasvir inhibition of OATP1B1, OATP1B3 and OATP2B1 reduces olmesartan uptake and clearance.
What to do
Monitor blood pressure and renal function during hepatitis C treatment, and lower the olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Olmesartan and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits intestinal and hepatic OATP transporters and may raise olmesartan concentrations. The result is possible enhanced blood pressure lowering or dose-related adverse effects.
How serious is the interaction between Olmesartan and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during hepatitis C treatment, and lower the olmesartan dose if hypotension occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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