Drug interactions
Olmesartan + Sulfasalazine
Severity: Minor
Olmesartan and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is not a typical NSAID in its effects on renal prostaglandins, and there is no well-established clinical interaction with olmesartan. Any effect on potassium or renal function is theoretical.
What this interaction means in plain words
Olmesartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; a theoretical renal prostaglandin or potassium effect is not well supported.
What to do
No specific action needed beyond routine monitoring of renal function and potassium in patients on olmesartan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Sulfasalazine?
MediHelp rates the interaction as minor. Olmesartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is not a typical NSAID in its effects on renal prostaglandins, and there is no well-established clinical interaction with olmesartan. Any effect on potassium or renal function is theoretical.
How serious is the interaction between Olmesartan and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed beyond routine monitoring of renal function and potassium in patients on olmesartan.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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