Drug interactions
Olmesartan + Synthetic human angiotensin ii
Severity: Moderate
Olmesartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan blocks the AT1 receptor through which angiotensin II raises blood pressure, so the pressor response to infused angiotensin II may be reduced. This may require higher infusion doses in patients with vasodilatory shock who are taking an ARB.
What this interaction means in plain words
Olmesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive antagonism of angiotensin II type 1 receptors by olmesartan.
What to do
Titrate angiotensin II to blood pressure response and anticipate a higher dose requirement in patients recently on olmesartan. Hold olmesartan in critically ill patients with shock.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Olmesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan blocks the AT1 receptor through which angiotensin II raises blood pressure, so the pressor response to infused angiotensin II may be reduced. This may require higher infusion doses in patients with vasodilatory shock who are taking an ARB.
How serious is the interaction between Olmesartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to blood pressure response and anticipate a higher dose requirement in patients recently on olmesartan. Hold olmesartan in critically ill patients with shock.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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