Drug interactions
Olmesartan + Xipamide
Severity: Moderate
Olmesartan and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, and combining it with olmesartan gives an additive antihypertensive effect, which is often intended. Volume depletion can cause excessive hypotension and renal impairment, particularly at initiation.
What this interaction means in plain words
Olmesartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood pressure lowering from diuretic-induced volume and sodium depletion plus angiotensin receptor blockade.
What to do
Monitor blood pressure, renal function and electrolytes after starting or changing doses. Consider a lower starting dose of either drug in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Xipamide?
MediHelp rates the interaction as moderate. Olmesartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic, and combining it with olmesartan gives an additive antihypertensive effect, which is often intended. Volume depletion can cause excessive hypotension and renal impairment, particularly at initiation.
How serious is the interaction between Olmesartan and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or changing doses. Consider a lower starting dose of either drug in volume-depleted patients.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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