Drug interactions
Olodaterol inhaled + Propranolol
Severity: Major
Olodaterol inhaled and Propranolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol antagonizes the bronchodilator effect of olodaterol and may provoke severe bronchospasm in patients with airway disease. Both therapeutic benefits can be lost.
What this interaction means in plain words
Olodaterol inhaled and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nonselective beta-2 receptor blockade by propranolol competitively opposes the beta-2 agonist.
What to do
Avoid propranolol in patients using olodaterol; if a beta-blocker is required, use a cardioselective agent with careful respiratory monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Olodaterol inhaled with Propranolol?
MediHelp rates the interaction as major. Olodaterol inhaled and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propranolol antagonizes the bronchodilator effect of olodaterol and may provoke severe bronchospasm in patients with airway disease. Both therapeutic benefits can be lost.
How serious is the interaction between Olodaterol inhaled and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propranolol in patients using olodaterol; if a beta-blocker is required, use a cardioselective agent with careful respiratory monitoring.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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