Drug interactions
Olopatadine intranasal + Remifentanil
Severity: Moderate
Olopatadine intranasal and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and opioids add to this sedation. Together they may increase psychomotor impairment and daytime drowsiness.
What this interaction means in plain words
Olopatadine intranasal and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Monitor sedation and counsel on impaired driving; consider an alternative non-sedating nasal therapy if drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Frequently asked questions
Can I take Olopatadine intranasal with Remifentanil?
MediHelp rates the interaction as moderate. Olopatadine intranasal and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause somnolence, and opioids add to this sedation. Together they may increase psychomotor impairment and daytime drowsiness.
How serious is the interaction between Olopatadine intranasal and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and counsel on impaired driving; consider an alternative non-sedating nasal therapy if drowsiness occurs.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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