Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Phenytoin
Severity: Contraindicated
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Phenytoin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin can reduce concentrations of paritaprevir, ritonavir, ombitasvir and dasabuvir, risking hepatitis C treatment failure.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Phenytoin induces CYP3A4 and CYP2C8, which clear the components of the regimen.
What to do
Do not co-administer; use a non-inducing anticonvulsant or an alternative HCV regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Phenytoin?
MediHelp rates the interaction as contraindicated. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin can reduce concentrations of paritaprevir, ritonavir, ombitasvir and dasabuvir, risking hepatitis C treatment failure.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-inducing anticonvulsant or an alternative HCV regimen.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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