Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Pimozide
Severity: Contraindicated
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This regimen contains ritonavir and paritaprevir, which inhibit CYP3A4 and can sharply increase pimozide levels. This raises the risk of QT prolongation and serious arrhythmias.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Ritonavir-boosted CYP3A4 inhibition reduces pimozide metabolism.
What to do
Do not coadminister. Use a different HCV regimen or switch pimozide before starting.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pimozide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Pimozide?
MediHelp rates the interaction as contraindicated. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This regimen contains ritonavir and paritaprevir, which inhibit CYP3A4 and can sharply increase pimozide levels. This raises the risk of QT prolongation and serious arrhythmias.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Use a different HCV regimen or switch pimozide before starting.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
