Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Pitavastatin
Severity: Major
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pitavastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paritaprevir inhibits OATP1B1/1B3 and can raise exposure to statins. Higher pitavastatin levels increase the risk of myopathy, and the labeling of the combination advises against pitavastatin use.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Paritaprevir inhibits OATP1B1/1B3 hepatic uptake of pitavastatin.
What to do
Avoid the combination if possible and hold pitavastatin during the antiviral course, or switch to a statin with a defined dose limit. Monitor for myopathy if coadministered.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Pitavastatin?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paritaprevir inhibits OATP1B1/1B3 and can raise exposure to statins. Higher pitavastatin levels increase the risk of myopathy, and the labeling of the combination advises against pitavastatin use.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pitavastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and hold pitavastatin during the antiviral course, or switch to a statin with a defined dose limit. Monitor for myopathy if coadministered.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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