Drug interactions
Omega + Vorapaxar
Severity: Moderate
Omega and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a potent antiplatelet agent with a notable bleeding risk. Omega-3 fatty acids at higher doses mildly affect platelet function and might add to that risk, although supporting clinical data are limited.
What this interaction means in plain words
Omega and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effect: omega-3 reduces platelet aggregation while vorapaxar blocks the PAR-1 thrombin receptor.
What to do
Monitor for bleeding and bruising, and avoid unnecessary high-dose omega-3 supplementation. Reassess the combination if any bleeding develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Omega with Vorapaxar?
MediHelp rates the interaction as moderate. Omega and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorapaxar is a potent antiplatelet agent with a notable bleeding risk. Omega-3 fatty acids at higher doses mildly affect platelet function and might add to that risk, although supporting clinical data are limited.
How serious is the interaction between Omega and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising, and avoid unnecessary high-dose omega-3 supplementation. Reassess the combination if any bleeding develops.
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