Drug interactions
Orphenadrine + Pimozide
Severity: Moderate
Orphenadrine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and anticholinergic, so combined use can cause drowsiness, confusion, dry mouth, urinary retention and constipation. Orphenadrine has also been linked to QT prolongation in overdose, which is relevant alongside pimozide.
What this interaction means in plain words
Orphenadrine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and anticholinergic effects.
What to do
Monitor for sedation and anticholinergic toxicity, especially in older adults. Consider an ECG if doses are high or other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Orphenadrine with Pimozide?
MediHelp rates the interaction as moderate. Orphenadrine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and anticholinergic, so combined use can cause drowsiness, confusion, dry mouth, urinary retention and constipation. Orphenadrine has also been linked to QT prolongation in overdose, which is relevant alongside pimozide.
How serious is the interaction between Orphenadrine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic toxicity, especially in older adults. Consider an ECG if doses are high or other QT-prolonging drugs are present.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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