Drug interactions
Paclitaxel protein bound + Phenytoin
Severity: Moderate
Paclitaxel protein bound and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP2C8 and CYP3A4 and may lower paclitaxel exposure, potentially reducing antitumor efficacy. Chemotherapy regimens can also alter phenytoin absorption or levels, causing seizure breakthrough.
What this interaction means in plain words
Paclitaxel protein bound and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenytoin induces CYP2C8/3A4-mediated paclitaxel metabolism, and chemotherapy may change phenytoin absorption or clearance.
What to do
Monitor phenytoin levels and seizure control, and consider a non-inducing anticonvulsant such as levetiracetam during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Paclitaxel protein bound with Phenytoin?
MediHelp rates the interaction as moderate. Paclitaxel protein bound and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces CYP2C8 and CYP3A4 and may lower paclitaxel exposure, potentially reducing antitumor efficacy. Chemotherapy regimens can also alter phenytoin absorption or levels, causing seizure breakthrough.
How serious is the interaction between Paclitaxel protein bound and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and seizure control, and consider a non-inducing anticonvulsant such as levetiracetam during treatment.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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