Drug interactions
Papaveretum + Pimozide
Severity: Moderate
Papaveretum and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opioid alkaloids (morphine), and combined with pimozide it can intensify sedation, respiratory depression and hypotension. The risk is higher in elderly or debilitated patients.
What this interaction means in plain words
Papaveretum and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from opioid and antipsychotic actions.
What to do
Start with the lowest effective opioid dose and monitor sedation, respiratory rate and blood pressure. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Papaveretum with Pimozide?
MediHelp rates the interaction as moderate. Papaveretum and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains opioid alkaloids (morphine), and combined with pimozide it can intensify sedation, respiratory depression and hypotension. The risk is higher in elderly or debilitated patients.
How serious is the interaction between Papaveretum and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective opioid dose and monitor sedation, respiratory rate and blood pressure. Counsel patients to avoid driving and alcohol.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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