Drug interactions
Papaveretum + Topiramate
Severity: Moderate
Papaveretum and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine and adds to topiramate's sedative effects. The combination can cause marked drowsiness and respiratory depression.
What this interaction means in plain words
Papaveretum and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid receptor agonism and topiramate's CNS effects.
What to do
Use the lowest effective opioid dose and monitor sedation and respiratory rate, especially at initiation. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Frequently asked questions
Can I take Papaveretum with Topiramate?
MediHelp rates the interaction as moderate. Papaveretum and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains opium alkaloids including morphine and adds to topiramate's sedative effects. The combination can cause marked drowsiness and respiratory depression.
How serious is the interaction between Papaveretum and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor sedation and respiratory rate, especially at initiation. Avoid alcohol and other sedatives.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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