Drug interactions
Parecoxib + Propranolol
Severity: Moderate
Parecoxib and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib can reduce the blood pressure lowering effect of beta-blockers. Renal function may also be affected in at-risk patients.
What this interaction means in plain words
Parecoxib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and fluid retention and vasoconstriction, opposing beta-blocker antihypertensive effect.
What to do
Monitor blood pressure during NSAID courses, and keep parecoxib use brief at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Parecoxib with Propranolol?
MediHelp rates the interaction as moderate. Parecoxib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib can reduce the blood pressure lowering effect of beta-blockers. Renal function may also be affected in at-risk patients.
How serious is the interaction between Parecoxib and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during NSAID courses, and keep parecoxib use brief at the lowest effective dose.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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