Drug interactions
Parecoxib + Telmisartan-amlodipine
Severity: Moderate
Parecoxib and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib can reduce the antihypertensive effect of telmisartan and impair renal function, particularly in volume-depleted or older patients. Hyperkalemia and acute kidney injury are possible.
What this interaction means in plain words
Parecoxib and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, opposing ARB action and adding to hyperkalemia risk.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the shortest possible NSAID course or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Frequently asked questions
Can I take Parecoxib with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Parecoxib and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib can reduce the antihypertensive effect of telmisartan and impair renal function, particularly in volume-depleted or older patients. Hyperkalemia and acute kidney injury are possible.
How serious is the interaction between Parecoxib and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the shortest possible NSAID course or an alternative analgesic.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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