Drug interactions
Penbutolol + Sildenafil
Severity: Minor
Penbutolol and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil adds vasodilation to a beta-blocker's blood pressure lowering effect, which may cause symptomatic hypotension in some patients.
What this interaction means in plain words
Penbutolol and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering through PDE5 inhibition and beta-adrenergic blockade.
What to do
Start sildenafil at a low dose and monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Frequently asked questions
Can I take Penbutolol with Sildenafil?
MediHelp rates the interaction as minor. Penbutolol and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sildenafil adds vasodilation to a beta-blocker's blood pressure lowering effect, which may cause symptomatic hypotension in some patients.
How serious is the interaction between Penbutolol and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at a low dose and monitor blood pressure and orthostatic symptoms.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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