Drug interactions
Penbutolol + Terbutaline
Severity: Major
Penbutolol and Terbutaline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penbutolol is a nonselective beta-blocker that blocks the beta-2 receptors terbutaline acts on, reducing or abolishing its bronchodilator effect. In patients with asthma or COPD this can provoke bronchospasm that responds poorly to usual doses of beta agonists.
What this interaction means in plain words
Penbutolol and Terbutaline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a nonselective beta-blocker.
What to do
Avoid nonselective beta-blockers in patients requiring terbutaline, particularly those with asthma; choose a cardioselective agent with caution if a beta-blocker is essential. Monitor respiratory status closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Terbutaline
Frequently asked questions
Can I take Penbutolol with Terbutaline?
MediHelp rates the interaction as major. Penbutolol and Terbutaline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penbutolol is a nonselective beta-blocker that blocks the beta-2 receptors terbutaline acts on, reducing or abolishing its bronchodilator effect. In patients with asthma or COPD this can provoke bronchospasm that responds poorly to usual doses of beta agonists.
How serious is the interaction between Penbutolol and Terbutaline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers in patients requiring terbutaline, particularly those with asthma; choose a cardioselective agent with caution if a beta-blocker is essential. Monitor respiratory status closely.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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