Drug interactions
Pentobarbital + Sildenafil
Severity: Moderate
Pentobarbital and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital can induce CYP3A4 and reduce sildenafil exposure, possibly weakening its effect. The effect is greater with repeated dosing.
What this interaction means in plain words
Pentobarbital and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturates induce CYP3A4, increasing sildenafil metabolism.
What to do
Monitor for reduced sildenafil efficacy, especially in pulmonary hypertension, and adjust the dose or choose an alternative if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Frequently asked questions
Can I take Pentobarbital with Sildenafil?
MediHelp rates the interaction as moderate. Pentobarbital and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital can induce CYP3A4 and reduce sildenafil exposure, possibly weakening its effect. The effect is greater with repeated dosing.
How serious is the interaction between Pentobarbital and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced sildenafil efficacy, especially in pulmonary hypertension, and adjust the dose or choose an alternative if needed.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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