Drug interactions
Peramivir + Tenofovir disoproxil
Severity: Minor
Peramivir and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peramivir is eliminated renally, and its exposure rises when kidney function declines. Tenofovir is nephrotoxic and may compete for renal tubular secretion, so peramivir levels may increase modestly. Clinical significance is usually small with a single peramivir dose.
What this interaction means in plain words
Peramivir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular elimination and tenofovir-associated reduction in renal function.
What to do
Check renal function before peramivir and adjust dose per label for creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Peramivir with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Peramivir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peramivir is eliminated renally, and its exposure rises when kidney function declines. Tenofovir is nephrotoxic and may compete for renal tubular secretion, so peramivir levels may increase modestly. Clinical significance is usually small with a single peramivir dose.
How serious is the interaction between Peramivir and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before peramivir and adjust dose per label for creatinine clearance.
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