Drug interactions
Perindopril + Phenoxybenzamine
Severity: Moderate
Perindopril and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine causes long-lasting alpha-blockade and, with perindopril, can lead to marked hypotension, especially after the first dose. Orthostatic symptoms and syncope are the main concerns.
What this interaction means in plain words
Perindopril and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from irreversible alpha-adrenergic blockade and ACE inhibition.
What to do
Introduce one agent at a time at low doses and monitor blood pressure including standing readings. Adjust doses to avoid symptomatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Perindopril and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine causes long-lasting alpha-blockade and, with perindopril, can lead to marked hypotension, especially after the first dose. Orthostatic symptoms and syncope are the main concerns.
How serious is the interaction between Perindopril and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Introduce one agent at a time at low doses and monitor blood pressure including standing readings. Adjust doses to avoid symptomatic hypotension.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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