Drug interactions
Perindopril + Prazosin
Severity: Moderate
Perindopril and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prazosin can cause a marked first-dose hypotensive response, which may be heightened by an ACE inhibitor. Dizziness and syncope may occur, especially when either drug is started.
What this interaction means in plain words
Perindopril and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perindopril belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 blockade and renin-angiotensin inhibition.
What to do
Start prazosin at a low dose at bedtime and titrate slowly, monitoring orthostatic blood pressure; consider reducing the perindopril dose initially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Perindopril with Prazosin?
MediHelp rates the interaction as moderate. Perindopril and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prazosin can cause a marked first-dose hypotensive response, which may be heightened by an ACE inhibitor. Dizziness and syncope may occur, especially when either drug is started.
How serious is the interaction between Perindopril and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start prazosin at a low dose at bedtime and titrate slowly, monitoring orthostatic blood pressure; consider reducing the perindopril dose initially.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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